Our Research Focus

At CounterionBio, our laboratory conducts small-scale studies in molecular formulation and analytical chemistry. We do not sell or distribute products. Instead, we perform controlled experimental work aimed at understanding molecular stability, solubility, and performance. Every study is carried out under defined conditions with full documentation suitable for scientific and regulatory contexts.

Peptide and Protein Formulation Studies

Stability and Solubility Profiling

We investigate peptide and protein behavior across pH, ionic strength, and solvent environments. This includes identifying optimal excipient combinations, assessing aggregation tendencies, and determining thermal and chemical stability profiles.

Counterion and Salt Form Screening

The choice of counterion can determine solubility, bioavailability, and solid-state properties. We perform targeted ion-pairing experiments to study how salt forms influence formulation performance and reconstitution behavior.

Lyophilization and Reconstitution Studies

We analyze peptide and protein samples through freeze-drying and rehydration to evaluate structural integrity, yield, and recovery. Results inform best practices for long-term storage and reconstitution methods.

Small-Molecule Formulation Research

Salt and Co-crystal Formation

We conduct systematic screening of acid-base pairs and co-formers to identify stable, manufacturable salt or co-crystal forms. Analytical data confirm purity, stability, and reproducibility.

Solvent and Excipient Compatibility

Our work examines solubilization strategies for poorly soluble compounds, including mixed solvent systems, surfactants, and stabilizing agents. Data support rational formulation design and preformulation assessment.

Analytical and Characterization Methods

Instrumental Analysis

We utilize LC-MS, HPLC, and UV-Vis methods to confirm purity, monitor degradation, and quantify concentration changes across experiments. Analytical reports are provided with all studies.

Physical and Chemical Stability Testing

We perform controlled stability testing under various environmental conditions such as temperature, light, and humidity to assess degradation kinetics and identify limiting factors in formulation performance.

Collaboration and Private Studies

All work at CounterionBio is privately arranged and conducted on a small scale. We do not publish client data or list partners.
Our laboratory operates independently, with strict confidentiality for all communications and results.

If you are seeking technical collaboration, feasibility testing, or formulation research on a private basis, please reach out via [email protected].